It follows Monk, a brilliant detective with obsessive-compulsive disorder. He returns to solve one last case involving his stepdaughter Molly, a journalist preparing for her wedding.

It's 1998 and over the course of one 12 Hour Shift at an Arkansas Hospital, A Junkie Nurse (Angela Bettis), Her Scheming Cousin (Chloe Farnworth) and a group of black market Organ-Trading criminals (Mick Foley, David Arquette, Dusty Warren) start a heist that could lead to all of their demise.